Structural basis for receptor recognition of vitamin-B12–intrinsic factor complexes

Christian Brix Folsted Andersen, Mette Madsen, Tina Storm, Søren K. Moestrup () and Gregers R. Andersen
Additional contact information
Christian Brix Folsted Andersen: Department of Medical Biochemistry,
Mette Madsen: Department of Medical Biochemistry,
Tina Storm: Department of Medical Biochemistry,
Søren K. Moestrup: Department of Medical Biochemistry,
Gregers R. Andersen: Aarhus University, 8000 Aarhus C, Denmark

Nature, 2010, vol. 464, issue 7287, 445-448

Abstract: Getting to grips with vitamin B12 Vitamin B12, or cobalamin (Cbl), is an essential coenzyme in mammals that has to be taken up from the diet. Intestinal uptake of the 'extrinsic factor' Cbl is a highly specific process, dependent on gastric intrinsic factor (IF) and the ileal endocytic cubam receptor formed by cubilin and amnionless. Loss of function of any of these proteins ultimately leads to Cbl deficiency in humans. The crystal structure of the complex between IF–Cbl and the cubilin IF–Cbl-binding region (CUB5–8) has now been determined at 3.3 Å resolution. The structure illuminates how multiple CUB domains collectively function as modular ligand-binding regions, and how two distant CUB domains bind the two IF domains in a Ca2+-dependent fashion.

Date: 2010
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature08874 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:464:y:2010:i:7287:d:10.1038_nature08874

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature08874

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().