Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes

Kazu Kikuchi, Jennifer E. Holdway, Andreas A. Werdich, Ryan M. Anderson, Yi Fang, Gregory F. Egnaczyk, Todd Evans, Calum A. MacRae, Didier Y. R. Stainier and Kenneth D. Poss ()
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Kazu Kikuchi: Department of Cell Biology,
Jennifer E. Holdway: Department of Cell Biology,
Andreas A. Werdich: Brigham and Women’s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
Ryan M. Anderson: University of California San Francisco, San Francisco, California 94158, USA
Yi Fang: Department of Cell Biology,
Gregory F. Egnaczyk: Department of Cell Biology,
Todd Evans: Weill Cornell Medical College, Cornell University, New York, New York 10021, USA
Calum A. MacRae: Brigham and Women’s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
Didier Y. R. Stainier: University of California San Francisco, San Francisco, California 94158, USA
Kenneth D. Poss: Department of Cell Biology,

Nature, 2010, vol. 464, issue 7288, 601-605

Abstract: Cardiac regeneration Zebrafish are able to efficiently regenerate lost cardiac muscle, and is used as a model to understand why natural heart regeneration is blocked in mammals. Two groups reporting in the issue of Nature used genetic fate-mapping approaches to identify which population of cardiomyocytes contribute prominently to cardiac muscle regeneration after an injury approximating myocardial infarction. They show that cardiac muscle regenerates through activation and expansion of existing cardiomyocytes, and does not involve activation of a stem cell population.

Date: 2010
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DOI: 10.1038/nature08804

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