Transcriptional control of preadipocyte determination by Zfp423

Rana K. Gupta, Zoltan Arany, Patrick Seale, Rina J. Mepani, Li Ye, Heather M. Conroe, Yang A. Roby, Heather Kulaga, Randall R. Reed and Bruce M. Spiegelman ()
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Rana K. Gupta: Harvard Medical School, Boston, Massachusetts 02115, USA
Zoltan Arany: Harvard Medical School, Boston, Massachusetts 02115, USA
Patrick Seale: Harvard Medical School, Boston, Massachusetts 02115, USA
Rina J. Mepani: Harvard Medical School, Boston, Massachusetts 02115, USA
Li Ye: Harvard Medical School, Boston, Massachusetts 02115, USA
Heather M. Conroe: Harvard Medical School, Boston, Massachusetts 02115, USA
Yang A. Roby: Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Heather Kulaga: Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Randall R. Reed: Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Bruce M. Spiegelman: Harvard Medical School, Boston, Massachusetts 02115, USA

Nature, 2010, vol. 464, issue 7288, 619-623

Abstract: Zfp423 involved in preadipose cell determination For the past 20 years extensive research from the adipogenesis field has focused almost exclusively on the transcriptional mechanisms governing the differentiation of committed fibroblastic fat cell precursors (preadipocytes) into mature adipocytes. This has led to the identification of a clutch of important regulators of adipocyte differentiation, including PPARγ and various C/EBP family members. Relatively little is known about the transcriptional mechanisms controlling the formation of preadipocytes rather that other fibroblastic cells — the so-called commitment step. Here, the zinc-finger protein Zfp423 is identified as a transcriptional regulator of preadipose cell determination.

Date: 2010
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DOI: 10.1038/nature08816

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