Whole-genome resequencing reveals loci under selection during chicken domestication

Carl-Johan Rubin, Michael C. Zody, Jonas Eriksson, Jennifer R. S. Meadows, Ellen Sherwood, Matthew T. Webster, Lin Jiang, Max Ingman, Ted Sharpe, Sojeong Ka, Finn Hallböök, Francois Besnier, Örjan Carlborg, Bertrand Bed’hom, Michèle Tixier-Boichard, Per Jensen, Paul Siegel, Kerstin Lindblad-Toh and Leif Andersson ()
Additional contact information
Carl-Johan Rubin: Uppsala University, Box 582, SE-75123 Uppsala, Sweden
Michael C. Zody: Uppsala University, Box 582, SE-75123 Uppsala, Sweden
Jonas Eriksson: Uppsala University, Box 582, SE-75123 Uppsala, Sweden
Jennifer R. S. Meadows: Uppsala University, Box 582, SE-75123 Uppsala, Sweden
Ellen Sherwood: Karolinska Institutet
Matthew T. Webster: Uppsala University, Box 582, SE-75123 Uppsala, Sweden
Lin Jiang: Uppsala University, Box 582, SE-75123 Uppsala, Sweden
Max Ingman: The Rudbeck Laboratory, Uppsala University
Ted Sharpe: Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
Sojeong Ka: Uppsala University
Finn Hallböök: Uppsala University
Francois Besnier: Swedish University of Agricultural Sciences, Box 597, SE-75124 Uppsala, Sweden
Örjan Carlborg: Swedish University of Agricultural Sciences, Box 597, SE-75124 Uppsala, Sweden
Bertrand Bed’hom: INRA, AgroParisTech, UMR1313 Animal Genetics and Integrative Biology
Michèle Tixier-Boichard: INRA, AgroParisTech, UMR1313 Animal Genetics and Integrative Biology
Per Jensen: IFM Biology, Linköping University
Paul Siegel: Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0306, USA
Kerstin Lindblad-Toh: Uppsala University, Box 582, SE-75123 Uppsala, Sweden
Leif Andersson: Uppsala University, Box 582, SE-75123 Uppsala, Sweden

Nature, 2010, vol. 464, issue 7288, 587-591

Abstract: Chicken and egg questions The domestication of the chicken over a period of several thousand years and its later specialization into meat producing (broiler) and egg producing (layer) lines is an informative model of domestication and phenotypic evolution. A study using massively parallel sequencing of domestic chicken and its wild ancestor, the red jungle fowl, reveals a number of 'selective sweeps', where benign genetic variations closely linked to a mutation that dramatically enhances survival increase in frequency relative to other alleles. Most striking of these — found in all domestic chickens — is one at a locus encoding thyroid stimulating hormone receptor, which has a key role in metabolism and vertebrate reproductive timing. This sweep may be related to a classic feature of domesticated animals, the absence of the strict regulation of seasonal reproduction found in wild populations. Several of the selective sweeps detected in broilers overlap genes associated with growth, appetite and metabolic regulation.

Date: 2010
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DOI: 10.1038/nature08832

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