A computational model of teeth and the developmental origins of morphological variation

Isaac Salazar-Ciudad () and Jukka Jernvall ()
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Isaac Salazar-Ciudad: Departament de Genètica i Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
Jukka Jernvall: Developmental Biology Program, Institute of Biotechnology, University of Helsinki, PO Box 56, FIN-00014 Helsinki, Finland

Nature, 2010, vol. 464, issue 7288, 583-586

Abstract: Phenotypes on the map The connection between genes (genotype) and the adult form of an organism (phenotype) is not a simple matter of one-to-one mapping. The nonlinear process of development intervenes, dependent on various genetic inputs and interactions between cells. Using a well studied system, the mammalian tooth, Isaac Salazar-Ciudad and Jukka Jernvall have developed a computational model to bridge the gap between genotype and phenotype. Based on data from seal teeth, which show extensive morphological variation, they find that a much of the dental variation can be explained by changes in single model parameters. This work could be a step towards understanding the contribution of genes and development to variation and, therefore, to evolution.

Date: 2010
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DOI: 10.1038/nature08838

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