Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

Chris Jopling, Eduard Sleep, Marina Raya, Mercè Martí, Angel Raya and Juan Carlos Izpisúa Belmonte ()
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Chris Jopling: Center of Regenerative Medicine in Barcelona,
Eduard Sleep: Center of Regenerative Medicine in Barcelona,
Marina Raya: Center of Regenerative Medicine in Barcelona,
Mercè Martí: Center of Regenerative Medicine in Barcelona,
Angel Raya: Center of Regenerative Medicine in Barcelona,
Juan Carlos Izpisúa Belmonte: Center of Regenerative Medicine in Barcelona,

Nature, 2010, vol. 464, issue 7288, 606-609

Abstract: Cardiac regeneration Zebrafish are able to efficiently regenerate lost cardiac muscle, and is used as a model to understand why natural heart regeneration is blocked in mammals. Two groups reporting in the issue of Nature used genetic fate-mapping approaches to identify which population of cardiomyocytes contribute prominently to cardiac muscle regeneration after an injury approximating myocardial infarction. They show that cardiac muscle regenerates through activation and expansion of existing cardiomyocytes, and does not involve activation of a stem cell population.

Date: 2010
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DOI: 10.1038/nature08899

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