Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells

Jason M. Kinchen () and Kodi S. Ravichandran ()
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Jason M. Kinchen: Center for Cell Clearance and,
Kodi S. Ravichandran: Center for Cell Clearance and,

Nature, 2010, vol. 464, issue 7289, 778-782

Abstract: Apoptosis: dealing with the corpse Apoptotic cells are removed from tissues through recognition and engulfment by phagocytes. While recent studies have identified receptors that mediate interactions between apoptotic cells and phagocytes, the molecular mechanisms underlying the degradation of apoptotic cells following engulfment remain unclear. Here, Jason Kinchen and Kodi Ravichandran identify two evolutionarily conserved genes that are required for the processing of ingested apoptotic cells in Caenorhabditis elegans and mammalian cells. These genes are required for phagosome maturation through a mechanism involving Rab conversion. As poor engulfment of apoptotic cells is associated with some diseases, understanding this process could lead to new treatments.

Date: 2010
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DOI: 10.1038/nature08853

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