Impaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia

Torfi Sigurdsson, Kimberly L. Stark, Maria Karayiorgou, Joseph A. Gogos () and Joshua A. Gordon ()
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Torfi Sigurdsson: Department of Psychiatry,
Kimberly L. Stark: Department of Psychiatry,
Maria Karayiorgou: Department of Psychiatry,
Joseph A. Gogos: Department of Physiology and Cellular Biophysics,
Joshua A. Gordon: Department of Psychiatry,

Nature, 2010, vol. 464, issue 7289, 763-767

Abstract: Schizophrenia connections The 22q11.2 microdeletion is one of the most reliable known genetic risk factors for schizophrenia. Mice with a disruption in the equivalent chromosomal region have problems with working memory, one feature of schizophrenia. Sigurdsson et al. show that these mice also have disruptions in synchronous firing between prefrontal cortex and hippocampal neurons, a phenomenon that has been linked to learning and memory, and which is also disrupted in schizophrenia patients. These findings suggest that disruption of communication between these brain regions may underlie schizophrenia, and efforts to ameliorate this disruption may lead to novel treatments.

Date: 2010
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DOI: 10.1038/nature08855

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