Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication

Bridgett M. vonHoldt, John P. Pollinger, Kirk E. Lohmueller, Eunjung Han, Heidi G. Parker, Pascale Quignon, Jeremiah D. Degenhardt, Adam R. Boyko, Dent A. Earl, Adam Auton, Andy Reynolds, Kasia Bryc, Abra Brisbin, James C. Knowles, Dana S. Mosher, Tyrone C. Spady, Abdel Elkahloun, Eli Geffen, Malgorzata Pilot, Wlodzimierz Jedrzejewski, Claudia Greco, Ettore Randi, Danika Bannasch, Alan Wilton, Jeremy Shearman, Marco Musiani, Michelle Cargill, Paul G. Jones, Zuwei Qian, Wei Huang, Zhao-Li Ding, Ya-ping Zhang, Carlos D. Bustamante, Elaine A. Ostrander, John Novembre and Robert K. Wayne ()
Additional contact information
Bridgett M. vonHoldt: 621 Charles E. Young Drive South, University of California, Los Angeles, California 90095, USA
John P. Pollinger: 621 Charles E. Young Drive South, University of California, Los Angeles, California 90095, USA
Kirk E. Lohmueller: Cornell University, Ithaca, New York 14853-2601, USA
Eunjung Han: University of California, Los Angeles, California 14853, USA
Heidi G. Parker: Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Pascale Quignon: Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Jeremiah D. Degenhardt: Cornell University, Ithaca, New York 14853-2601, USA
Adam R. Boyko: Cornell University, Ithaca, New York 14853-2601, USA
Dent A. Earl: University of California, Santa Cruz, California 95064, USA
Adam Auton: Cornell University, Ithaca, New York 14853-2601, USA
Andy Reynolds: Cornell University, Ithaca, New York 14853-2601, USA
Kasia Bryc: Cornell University, Ithaca, New York 14853-2601, USA
Abra Brisbin: Cornell University, Ithaca, New York 14853-2601, USA
James C. Knowles: 621 Charles E. Young Drive South, University of California, Los Angeles, California 90095, USA
Dana S. Mosher: Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Tyrone C. Spady: Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Abdel Elkahloun: Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Eli Geffen: Tel Aviv University
Malgorzata Pilot: Museum and Institute of Zoology, Polish Academy of Sciences, Wilcza 64, 00-679 Warszawa, Poland
Wlodzimierz Jedrzejewski: Mammal Research Institute, Polish Academy of Sciences
Claudia Greco: Instituto Superiore per la Protezione e la Ricerca Ambientale (ISPRA)
Ettore Randi: Instituto Superiore per la Protezione e la Ricerca Ambientale (ISPRA)
Danika Bannasch: School of Veterinary Medicine, University of California, Davis, California 95616, USA
Alan Wilton: School of Biotechnology and Biomolecular Sciences and Clive and Vera Ramaciotti Center for Gene Function Analysis, University of New South Wales
Jeremy Shearman: School of Biotechnology and Biomolecular Sciences and Clive and Vera Ramaciotti Center for Gene Function Analysis, University of New South Wales
Marco Musiani: Faculty of Environmental Design, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada
Michelle Cargill: Affymetrix Corporation, 3420 Central Expressway, Santa Clara, California 95051, USA
Paul G. Jones: The WALTHAM Centre for Pet Nutrition, Waltham on the Worlds, Leicestershire LE14 4RT, UK
Zuwei Qian: Affymetrix Asia Pacific, Scientific Affairs and Collaborations, 1233 Lujiazui Ring Road, AZIA Center, Suite 1508, Shanghai 200120, China
Wei Huang: Affymetrix Asia Pacific, Scientific Affairs and Collaborations, 1233 Lujiazui Ring Road, AZIA Center, Suite 1508, Shanghai 200120, China
Zhao-Li Ding: Laboratory for Conservation and Utilization of Bio-resources, Yunnan University
Ya-ping Zhang: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
Carlos D. Bustamante: Cornell University, Ithaca, New York 14853-2601, USA
Elaine A. Ostrander: Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
John Novembre: 621 Charles E. Young Drive South, University of California, Los Angeles, California 90095, USA
Robert K. Wayne: 621 Charles E. Young Drive South, University of California, Los Angeles, California 90095, USA

Nature, 2010, vol. 464, issue 7290, 898-902

Abstract: Dog breeds, old and new The development of the domestic dog is a fascinating example of a dramatic radiation in form and function that has occurred rapidly in association with the expansion of human civilization. An extensive genome-wide survey of over 48,000 single nucleotide polymorphisms in dogs and their wild progenitor, the grey wolf, reveals striking patterns of genetic subdivision. Two clearly divergent clusters emerge, one of ancient breeds and the other of modern breeds created in the nineteenth century. An analysis of haplotype sharing suggests that the dog has a dominant Middle Eastern or European origin, consistent with recent archaeological finds, rather than one in East Asia as suggested previously by mitochondrial DNA data.

Date: 2010
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DOI: 10.1038/nature08837

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