Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET

Toshiyuki Matsui, Danny Leung, Hiroki Miyashita, Irina A. Maksakova, Hitoshi Miyachi, Hiroshi Kimura, Makoto Tachibana, Matthew C. Lorincz () and Yoichi Shinkai ()
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Toshiyuki Matsui: Experimental Research Center for Infectious Diseases, Institute for Virus Research, and,
Danny Leung: Life Sciences Institute, The University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
Hiroki Miyashita: Experimental Research Center for Infectious Diseases, Institute for Virus Research, and,
Irina A. Maksakova: Life Sciences Institute, The University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
Hitoshi Miyachi: Experimental Research Center for Infectious Diseases, Institute for Virus Research, and,
Hiroshi Kimura: Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan
Makoto Tachibana: Experimental Research Center for Infectious Diseases, Institute for Virus Research, and,
Matthew C. Lorincz: Life Sciences Institute, The University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
Yoichi Shinkai: Experimental Research Center for Infectious Diseases, Institute for Virus Research, and,

Nature, 2010, vol. 464, issue 7290, 927-931

Abstract: Stem cell proviral silencing Endogenous retroviruses are widely dispersed in mammalian genomes, and are silenced in somatic cells by DNA methylation. Here, an endogenous retroviruses silencing pathway independent of DNA methylation is shown to operate in embryonic stem cells. The pathway involves the histone H3K9 methyltransferase ESET/SETDB1 and might be important for endogenous retrovirus silencing during the stages in embryogenesis when DNA methylation is reprogrammed.

Date: 2010
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DOI: 10.1038/nature08858

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