Chromatin signature of embryonic pluripotency is established during genome activation

Nadine L. Vastenhouw, Yong Zhang, Ian G. Woods, Farhad Imam, Aviv Regev, X. Shirley Liu (), John Rinn and Alexander F. Schier ()
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Nadine L. Vastenhouw: Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
Yong Zhang: Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Ian G. Woods: Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
Farhad Imam: Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
Aviv Regev: Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
X. Shirley Liu: Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, Massachusetts 02115, USA
John Rinn: Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Alexander F. Schier: Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA

Nature, 2010, vol. 464, issue 7290, 922-926

Abstract: Chromatin signature of pluripotency To study the changes in chromatin structure that accompany zygotic genome activation and pluripotency during the maternal–zygotic transition (MZT), the genomic locations of histone H3 modifications and RNA polymerase II have been mapped during this transition in zebrafish embryos. H3 lysine 27 trimethylation and H3 lysine 4 trimethylation are only detected after MZT, and evidence is provided that the bivalent chromatin domains in cultured ES cells also exist in embryos.

Date: 2010
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DOI: 10.1038/nature08866

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