Double Holliday junctions are intermediates of DNA break repair

Malgorzata Bzymek, Nathaniel H. Thayer, Steve D. Oh, Nancy Kleckner and Neil Hunter ()
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Malgorzata Bzymek: Department of Microbiology,
Nathaniel H. Thayer: Molecular and Cellular Biology PhD Program, University of Washington, Seattle, Washington 98195-7275, USA
Steve D. Oh: University of California, San Francisco, California 94143-0511, USA
Nancy Kleckner: Harvard University, Cambridge, Massachusetts 02138, USA
Neil Hunter: Department of Microbiology,

Nature, 2010, vol. 464, issue 7290, 937-941

Abstract: DNA repair intermediates In meiotic cells, it is well established that the paired homologues are joined by a set of crossovers known as a double Holliday junction (DHJ). Whether DHJs form during mitotic recombination has been unclear, since mitotic cells possess alternative repair pathways that would not require DHJ formation. Bzymek et al. now demonstrate that mitotic and meiotic cells form similar DHJs, but that the levels in mitotic cells are approximately 10-fold lower, and show a preference for joints between sister chromatids rather than homologues. Consequently in mitotic cells non-crossover outcomes are favoured.

Date: 2010
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DOI: 10.1038/nature08868

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