The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

Jun Huang, Veronika I. Zarnitsyna, Baoyu Liu, Lindsay J. Edwards, Ning Jiang, Brian D. Evavold () and Cheng Zhu ()
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Jun Huang: Georgia Institute of Technology, Atlanta, Georgia 30332, USA
Veronika I. Zarnitsyna: Georgia Institute of Technology, Atlanta, Georgia 30332, USA
Baoyu Liu: Georgia Institute of Technology, Atlanta, Georgia 30332, USA
Lindsay J. Edwards: Emory University School of Medicine, Atlanta, Georgia 30322, USA
Ning Jiang: Georgia Institute of Technology, Atlanta, Georgia 30332, USA
Brian D. Evavold: Emory University School of Medicine, Atlanta, Georgia 30322, USA
Cheng Zhu: Georgia Institute of Technology, Atlanta, Georgia 30332, USA

Nature, 2010, vol. 464, issue 7290, 932-936

Abstract: Two-dimensional kinetics of TCR recognition Studies of the interaction between T-cell receptors (TCRs) and the peptide-major histocompatibility complex (pMHC), which is central to discrimination between pathogens and self antigens, have generally involved 'three-dimensional' analysis, with one of the interacting partners in solution. The resulting kinetic data have not adequately recorded the T-cell response. In reality TCR–pMHC interactions occur in two dimensions, at points of contact between two cells. Here Huang et al. show that two-dimensional TCR–pMHC-binding parameters accurately match the extent of the T-cell response.

Date: 2010
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DOI: 10.1038/nature08944

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