Vascular endothelial growth factor B controls endothelial fatty acid uptake

Carolina E. Hagberg, Annelie Falkevall, Xun Wang, Erik Larsson, Jenni Huusko, Ingrid Nilsson, Laurens A. van Meeteren, Erik Samen, Li Lu, Maarten Vanwildemeersch, Joakim Klar, Guillem Genove, Kristian Pietras, Sharon Stone-Elander, Lena Claesson-Welsh, Seppo Ylä-Herttuala, Per Lindahl and Ulf Eriksson ()
Additional contact information
Carolina E. Hagberg: Tissue Biology Group, Karolinska Institutet
Annelie Falkevall: Tissue Biology Group, Karolinska Institutet
Xun Wang: Tissue Biology Group, Karolinska Institutet
Erik Larsson: Institute of Biomedicine, University of Gothenburg, Box 440, SE-405 30 Gothenburg, Sweden
Jenni Huusko: A.I. Virtanen Institute, University of Kuopio, Box 1627, FIN-70211 Kuopio, Finland
Ingrid Nilsson: Tissue Biology Group, Karolinska Institutet
Laurens A. van Meeteren: Uppsala University, Rudbeck Laboratory
Erik Samen: Karolinska Pharmacy, Karolinska University Hospital, Solna, SE-17176 Stockholm, Sweden
Li Lu: Clinical Neurosciences, Karolinska Institutet
Maarten Vanwildemeersch: Tissue Biology Group, Karolinska Institutet
Joakim Klar: Ludwig Institute for Cancer Research Ltd, Stockholm Branch, Karolinska Institutet, Box 240, SE-171 77 Stockholm, Sweden
Guillem Genove: Laboratory of Vascular Biology, Karolinska Institutet
Kristian Pietras: Tissue Biology Group, Karolinska Institutet
Sharon Stone-Elander: Karolinska Pharmacy, Karolinska University Hospital, Solna, SE-17176 Stockholm, Sweden
Lena Claesson-Welsh: Uppsala University, Rudbeck Laboratory
Seppo Ylä-Herttuala: A.I. Virtanen Institute, University of Kuopio, Box 1627, FIN-70211 Kuopio, Finland
Per Lindahl: Institute of Biomedicine, University of Gothenburg, Box 440, SE-405 30 Gothenburg, Sweden
Ulf Eriksson: Tissue Biology Group, Karolinska Institutet

Nature, 2010, vol. 464, issue 7290, 917-921

Abstract: Lipids on the move VEGF-B, a vascular endothelial growth factor that is highly expressed in heart, skeletal muscle and brown adipose tissue, has been found to have an unexpected role in targeting lipids to peripheral tissues. VEGFs are familiar as major angiogenic regulators, but the detailed role of VEGF-B in blood vessel function had been unclear. Mice lacking VEGF-B accumulate lower amounts of lipids in muscle, heart and brown adipose tissue, and instead shunt them to white adipose tissue. The involvement of VEGF-B in redistributing lipids suggest possible novel strategies for modulating lipid accumulation in diabetes, obesity and cardiovascular diseases.

Date: 2010
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DOI: 10.1038/nature08945

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