Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis

Ling Zhang, Xiaoyang Ren, Eckhard Alt, Xiaowen Bai, Shaoyi Huang, Zhengming Xu, Patrick M. Lynch, Mary P. Moyer, Xian-Feng Wen and Xiangwei Wu ()
Additional contact information
Ling Zhang: Department of Head and Neck Surgery,
Xiaoyang Ren: Department of Head and Neck Surgery,
Eckhard Alt: Department of Molecular Pathology,
Xiaowen Bai: Department of Molecular Pathology,
Shaoyi Huang: Department of Head and Neck Surgery,
Zhengming Xu: Department of Head and Neck Surgery,
Patrick M. Lynch: Hepatology and Nutrition, and
Mary P. Moyer: INCELL Corporation, San Antonio, Texas 78249, USA
Xian-Feng Wen: Department of Head and Neck Surgery,
Xiangwei Wu: Department of Head and Neck Surgery,

Nature, 2010, vol. 464, issue 7291, 1058-1061

Abstract: Induced apoptosis as anticancer therapy The membrane-bound tumour necrosis factor-related ligand TRAIL (also called TNFSF10 and Apo2L) is known to induce apoptosis or cell death in cancer cells but not in normal cells. With a view to developing a way of specifically targeting premalignant tumour cells for apoptosis, Zhang et al. report that in a mouse model a combination of TRAIL and all-trans-retinyl acetate (RAc) causes premalignant intestinal polyp or adenoma cells lacking the APC (adenomatous polyposis coli) gene to undergo apoptosis. Normal cells appear unaffected by the treatment, suggesting that the therapy, which also has the advantage of requiring short, intermittent treatment cycles rather than long-term exposure, could prove useful in preventing human colon cancer.

Date: 2010
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DOI: 10.1038/nature08871

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