APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex

Yutaka Shimomura, Dritan Agalliu, Alin Vonica, Victor Luria, Muhammad Wajid, Alessandra Baumer, Serena Belli, Lynn Petukhova, Albert Schinzel, Ali H. Brivanlou, Ben A. Barres and Angela M. Christiano ()
Additional contact information
Yutaka Shimomura: Department of Dermatology,
Dritan Agalliu: Stanford University, Stanford, California 94305, USA
Alin Vonica: The Laboratory of Vertebrate Embryology, The Rockefeller University, New York, New York 10065, USA
Victor Luria: Department of Dermatology,
Muhammad Wajid: Department of Dermatology,
Alessandra Baumer: Institute of Medical Genetics, University of Zurich
Serena Belli: Struttura Semplice Genetica Medica APSS
Lynn Petukhova: Department of Dermatology,
Albert Schinzel: Institute of Medical Genetics, University of Zurich
Ali H. Brivanlou: The Laboratory of Vertebrate Embryology, The Rockefeller University, New York, New York 10065, USA
Ben A. Barres: Stanford University, Stanford, California 94305, USA
Angela M. Christiano: Department of Dermatology,

Nature, 2010, vol. 464, issue 7291, 1043-1047

Abstract: The routes of hair growth Hair follicle miniaturization is a degenerative process that reduces the dimensions of the epithelial and mesenchymal cell compartments, converting thick hair to fine, downy hair. It is most commonly observed in androgenetic alopecia, but is also characteristic of a rare form of hair loss known as hereditary hypotrichosis simplex (HHS). The gene involved in HHS has now been identified by genetic linkage analysis in affected families as APCDD1, which encodes a membrane-bound glycoprotein abundantly expressed in human hair follicles. Functional studies show that APCDD1 inhibits Wnt signalling, and is thus a potentially important component of signal transduction pathways in the hair follicle.

Date: 2010
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DOI: 10.1038/nature08875

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