Fructose 1,6-bisphosphate aldolase/phosphatase may be an ancestral gluconeogenic enzyme

Rafael F. Say and Georg Fuchs ()
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Rafael F. Say: Mikrobiologie, Fakultät Biologie, Universität Freiburg, Schänzlestraße 1, D-79104 Freiburg, Germany
Georg Fuchs: Mikrobiologie, Fakultät Biologie, Universität Freiburg, Schänzlestraße 1, D-79104 Freiburg, Germany

Nature, 2010, vol. 464, issue 7291, 1077-1081

Abstract: An ancestral gluconeogenic enzyme Many thermophilic bacteria and archaea use carbon dioxide or carbon monoxide as starting materials for the synthesis of organic material used for cellular molecules. A central enzyme in this pathway has now been identified as fructose 1,6-bisphosphate aldolase/phosphatase. This enzyme, which is missing in most other bacteria and in eukaryotes, has the characteristics required for a primordial autotrophic carbon metabolism. This adds supporting evidence for the hypothesis that life originated in a chemolithoautrophic thermophile and that glucogenesis evolved before glycolysis. This robust enzyme may also be biotechnologically valuable in producing engineered cells specialized for the production of carbohydrates.

Date: 2010
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DOI: 10.1038/nature08884

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