Functional genomic screen for modulators of ciliogenesis and cilium length

Joon Kim, Ji Eun Lee, Susanne Heynen-Genel, Eigo Suyama, Keiichiro Ono, KiYoung Lee, Trey Ideker, Pedro Aza-Blanc and Joseph G. Gleeson ()
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Joon Kim: Institute for Genomic Medicine, Howard Hughes Medical Institute, University of California San Diego, La Jolla, California 92093, USA
Ji Eun Lee: Institute for Genomic Medicine, Howard Hughes Medical Institute, University of California San Diego, La Jolla, California 92093, USA
Susanne Heynen-Genel: High Content Screening and Functional Genomics Core, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA
Eigo Suyama: High Content Screening and Functional Genomics Core, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA
Keiichiro Ono: University of California San Diego, La Jolla, California 92093, USA
KiYoung Lee: University of California San Diego, La Jolla, California 92093, USA
Trey Ideker: University of California San Diego, La Jolla, California 92093, USA
Pedro Aza-Blanc: High Content Screening and Functional Genomics Core, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA
Joseph G. Gleeson: Institute for Genomic Medicine, Howard Hughes Medical Institute, University of California San Diego, La Jolla, California 92093, USA

Nature, 2010, vol. 464, issue 7291, 1048-1051

Abstract: Screening for ciliogenesis genes Primary cilia are tiny hair-like structures expressed on the surface of eukaryotic cells. They participate in a wide range of biological processes such as sensing the extracellular environment to regulating numerous signalling pathways during development. Ciliary dysfunction has been linked to a group of human disorders known as ciliopathies. This study presents a functional genomic screen using RNA interference (RNAi) to identify human genes involved in control of ciliogenesis. Several positive and negative modulators of ciliogenesis with broad ranging functions were identified. Development of specific inhibitors that target key proteins may provide novel strategies to treat ciliopathies.

Date: 2010
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DOI: 10.1038/nature08895

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