CpG islands influence chromatin structure via the CpG-binding protein Cfp1

John P. Thomson, Peter J. Skene, Jim Selfridge, Thomas Clouaire, Jacky Guy, Shaun Webb, Alastair R. W. Kerr, Aimée Deaton, Rob Andrews, Keith D. James, Daniel J. Turner, Robert Illingworth and Adrian Bird ()
Additional contact information
John P. Thomson: Wellcome Trust Centre for Cell Biology, Michael Swann Building, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK
Peter J. Skene: Wellcome Trust Centre for Cell Biology, Michael Swann Building, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK
Jim Selfridge: Wellcome Trust Centre for Cell Biology, Michael Swann Building, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK
Thomas Clouaire: Wellcome Trust Centre for Cell Biology, Michael Swann Building, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK
Jacky Guy: Wellcome Trust Centre for Cell Biology, Michael Swann Building, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK
Shaun Webb: Wellcome Trust Centre for Cell Biology, Michael Swann Building, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK
Alastair R. W. Kerr: Wellcome Trust Centre for Cell Biology, Michael Swann Building, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK
Aimée Deaton: Wellcome Trust Centre for Cell Biology, Michael Swann Building, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK
Rob Andrews: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Keith D. James: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Daniel J. Turner: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Robert Illingworth: Wellcome Trust Centre for Cell Biology, Michael Swann Building, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK
Adrian Bird: Wellcome Trust Centre for Cell Biology, Michael Swann Building, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK

Nature, 2010, vol. 464, issue 7291, 1082-1086

Abstract: CpG islands and chromatin modification Most human gene promoters are embedded within CpG islands that lack DNA methylation and coincide with sites of histone H3 lysine 4 trimethylation (H3K4me3), irrespective of transcriptional activity. Here, a zinc-finger protein Cfp1 is found to be associated with non-methylated CpG islands and sites of H3K4me3 genome-wide in vivo. Cfp1 is part of the Setd1 complex which trimethylates H3K4. Artificial CpG clusters are shown to recruit Cfp1, leading to novel peaks of H3K4me3. Therefore a primary function of non-methylated CpG islands might be to genetically determine the local chromatin modification state.

Date: 2010
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DOI: 10.1038/nature08924

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