Migrastatin analogues target fascin to block tumour metastasis

Lin Chen, Shengyu Yang, Jean Jakoncic, J. Jillian Zhang and Xin-Yun Huang ()
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Lin Chen: Cornell University Weill Medical College, New York, New York 10065, USA
Shengyu Yang: Cornell University Weill Medical College, New York, New York 10065, USA
Jean Jakoncic: Brookhaven National Laboratory, National Synchrotron Light Source, Upton, New York 11973, USA
J. Jillian Zhang: Cornell University Weill Medical College, New York, New York 10065, USA
Xin-Yun Huang: Cornell University Weill Medical College, New York, New York 10065, USA

Nature, 2010, vol. 464, issue 7291, 1062-1066

Abstract: Fascin an anticancer target Analogues of the natural product migrastatin are potent inhibitors of tumour cell migration and metastasis. In this study, Lin Chen et al. elucidate the mechanism involved and show that these migrastatin analogues target and inhibit the activity of the actin bundling protein, fascin. These results suggest that actin cytoskeletal proteins, such as fascin, may present new molecular targets for cancer treatment.

Date: 2010
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DOI: 10.1038/nature08978

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