Extreme makeover of pancreatic α-cells

Kenneth S. Zaret and Morris F. White
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Kenneth S. Zaret: Kenneth S. Zaret is at the Institute for Regenerative Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. zaret@upenn.edu
Morris F. White: Morris F. White is at the Howard Hughes Medical Institute, Children's Hospital Boston, and at the Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. morris.white@childrens.harvard.edu

Nature, 2010, vol. 464, issue 7292, 1132-1133

Abstract: Most insulin-secreting pancreatic β-cells are irreplaceably lost in type 1 diabetes. In a mouse model, pancreatic α-cells seem to sacrifice their identity to replenish the low stock of β-cells1. Two experts discuss what this means for understanding the basic cell biology involved and its relevance to treating diabetes.boxed-text

Date: 2010
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DOI: 10.1038/4641132a

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