MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis

Stefania Nicoli, Clive Standley, Paul Walker, Adam Hurlstone, Kevin E. Fogarty and Nathan D. Lawson ()
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Stefania Nicoli: Program in Gene Function and Expression,
Clive Standley: Biomedical Imaging Group, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Paul Walker: Molecular Cancer Studies Group, Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
Adam Hurlstone: Molecular Cancer Studies Group, Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
Kevin E. Fogarty: Biomedical Imaging Group, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nathan D. Lawson: Program in Gene Function and Expression,

Nature, 2010, vol. 464, issue 7292, 1196-1200

Abstract: Angiogenesis: grow with the flow During embryogenesis, blood vessels are remodelled in response to blood flow. Nicoli et al. describe a genetic pathway that explains how this mechanosensory stimulus is integrated with early developmental signals to remodel aortic arch vessels in zebrafish. The flow-induced transcription factor klf2a is required for the induction of an endothelial cell-specific microRNA, miR-126, which promotes VEGF signalling and angiogenesis through repressing Spred1, an inhibitor of VEGF signalling. This demonstrates how blood flow modulates endothelial cell-signalling pathways and implicates a microRNA as a central integration point during this process.

Date: 2010
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DOI: 10.1038/nature08889

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