Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

Daniel R. Neill, See Heng Wong, Agustin Bellosi, Robin J. Flynn, Maria Daly, Theresa K. A. Langford, Christine Bucks, Colleen M. Kane, Padraic G. Fallon, Richard Pannell, Helen E. Jolin and Andrew N. J. McKenzie ()
Additional contact information
Daniel R. Neill: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
See Heng Wong: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Agustin Bellosi: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Robin J. Flynn: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Maria Daly: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Theresa K. A. Langford: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Christine Bucks: Immunology Discovery Research, Centocor R&D Inc., 145 King of Prussia Road, Radnor, Pennsylvania 19087, USA
Colleen M. Kane: Immunology Discovery Research, Centocor R&D Inc., 145 King of Prussia Road, Radnor, Pennsylvania 19087, USA
Padraic G. Fallon: Institute of Molecular Medicine, Trinity College Dublin
Richard Pannell: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Helen E. Jolin: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Andrew N. J. McKenzie: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK

Nature, 2010, vol. 464, issue 7293, 1367-1370

Abstract: Innate immunity: two lines of defence Type-2 immunity, the ancient defence mechanism that provides protection against gastrointestinal helminth infections, involves the recruitment of T helper (TH) cells that produce immune mediators or cytokines to coordinate an immune response involving IgE antibody production, the recruitment of eosinophils and goblet cell hyperplasia. Two groups reporting in this issue have characterized innate type 2 effector leukocyte populations that promote TH2 cytokine responses. Saenz et al. describe multipotent progenitor type-2 (MPPtype2) cells that accumulate in response to the cytokine IL-25 (interleukin-25) and give rise to macrophage or granulocyte lineages promoting TH2 differentiation. Neill et al. describe 'nuocytes', induced by IL25 and IL33, which are the predominant early source of IL13 during a helminth infection. In News & Views, Gérard Eberl discusses how these two papers — and a third in Nature Reviews Immunology ( http://go.nature.com/sJ9D77 ) — influence current thinking on the role of innate immunity.

Date: 2010
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DOI: 10.1038/nature08900

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