IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses

Steven A. Saenz, Mark C. Siracusa, Jacqueline G. Perrigoue, Sean P. Spencer, Joseph F. Urban, Joel E. Tocker, Alison L. Budelsky, Melanie A. Kleinschek, Robert A. Kastelein, Taku Kambayashi, Avinash Bhandoola and David Artis ()
Additional contact information
Steven A. Saenz: Department of Pathobiology,
Mark C. Siracusa: Department of Pathobiology,
Jacqueline G. Perrigoue: Department of Pathobiology,
Sean P. Spencer: Department of Pathobiology,
Joseph F. Urban: Diet, Genomics, & Immunology Lab, Beltsville Human Nutrition Research Center, Beltsville, Maryland 20705, USA
Joel E. Tocker: Amgen, Seattle, Washington 98119, USA
Alison L. Budelsky: Amgen, Seattle, Washington 98119, USA
Melanie A. Kleinschek: Discovery Research, Schering-Plough Biopharma, Palo Alto, California 94304, USA
Robert A. Kastelein: Discovery Research, Schering-Plough Biopharma, Palo Alto, California 94304, USA
Taku Kambayashi: University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Avinash Bhandoola: University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
David Artis: Department of Pathobiology,

Nature, 2010, vol. 464, issue 7293, 1362-1366

Abstract: Innate immunity: two lines of defence Type-2 immunity, the ancient defence mechanism that provides protection against gastrointestinal helminth infections, involves the recruitment of T helper (TH) cells that produce immune mediators or cytokines to coordinate an immune response involving IgE antibody production, the recruitment of eosinophils and goblet cell hyperplasia. Two groups reporting in this issue have characterized innate type 2 effector leukocyte populations that promote TH2 cytokine responses. Saenz et al. describe multipotent progenitor type-2 (MPPtype2) cells that accumulate in response to the cytokine IL-25 (interleukin-25) and give rise to macrophage or granulocyte lineages promoting TH2 differentiation. Neill et al. describe 'nuocytes', induced by IL25 and IL33, which are the predominant early source of IL13 during a helminth infection. In News & Views, Gérard Eberl discusses how these two papers — and a third in Nature Reviews Immunology ( http://go.nature.com/sJ9D77 ) — influence current thinking on the role of innate immunity.

Date: 2010
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DOI: 10.1038/nature08901

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