Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling

Pietro Fazzari, Ana V. Paternain, Manuel Valiente, Ramón Pla, Rafael Luján, Kent Lloyd, Juan Lerma, Oscar Marín () and Beatriz Rico ()
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Pietro Fazzari: Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández
Ana V. Paternain: Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández
Manuel Valiente: Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández
Ramón Pla: Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández
Rafael Luján: Facultad de Medicina, Universidad de Castilla-La Mancha
Kent Lloyd: California National Primate Research Center, University of California, Davis, California 95616, USA
Juan Lerma: Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández
Oscar Marín: Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández
Beatriz Rico: Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández

Nature, 2010, vol. 464, issue 7293, 1376-1380

Abstract: Inhibitory synapses: making connections Although several synaptic adhesion proteins have been identified as genetic risk factors in schizophrenia, it is unclear what role they may play in disease progression. A new study suggests that Neuregulin-1 (Nrg1) and its receptor ErbB4 function to regulate the connectivity of specific inhibitory cortical circuits. With so little known about how inhibitory synapses are made, this study provides important evidence implicating Nrg1/ErbB4 signalling in this process, as well as providing a perspective on how these genes may be involved in the onset of schizophrenia.

Date: 2010
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DOI: 10.1038/nature08928

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