Genetics, pathogenesis and clinical interventions in type 1 diabetes

Jeffrey A. Bluestone (), Kevan Herold and George Eisenbarth
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Jeffrey A. Bluestone: University of California, San Francisco, San Francisco, California 94143, USA
Kevan Herold: Yale University, New Haven, Connecticut 06520, USA
George Eisenbarth: Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, Colorado 80045-6511, USA

Nature, 2010, vol. 464, issue 7293, 1293-1300

Abstract: Understanding diabetes The clinical picture of type 1 diabetes — a progressive loss of pancreatic β-cell function and a requirement for daily insulin treatment — has been apparent for over a century but the precise nature of the disease progression continues to emerge. Recent progress towards understanding the pathogenetics and genetics of diabetes has been rapid, thanks to extensive research in rodent models and in diabetes patients. A review by Jeffrey Bluestone, Kevan Herold and George Eisenbarth recaps some of the major developments of the past decade and reports on the exciting new clinical interventions that are now being tested, some with the potential to be adapted for use in autoimmune diseases other than diabetes.

Date: 2010
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DOI: 10.1038/nature08933

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