NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Peter Duewell, Hajime Kono, Katey J. Rayner, Cherilyn M. Sirois, Gregory Vladimer, Franz G. Bauernfeind, George S. Abela, Luigi Franchi, Gabriel Nuñez, Max Schnurr, Terje Espevik, Egil Lien, Katherine A. Fitzgerald, Kenneth L. Rock, Kathryn J. Moore, Samuel D. Wright, Veit Hornung and Eicke Latz ()
Additional contact information
Peter Duewell: Department of Infectious Diseases and Immunology and,
Hajime Kono: University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Katey J. Rayner: New York University, New York, New York 10016, USA
Cherilyn M. Sirois: Department of Infectious Diseases and Immunology and,
Gregory Vladimer: Department of Infectious Diseases and Immunology and,
Franz G. Bauernfeind: Institute of Clinical Chemistry and Pharmacology and,
George S. Abela: Michigan State University, East Lansing, Michigan 48824, USA
Luigi Franchi: University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Gabriel Nuñez: University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Max Schnurr: University of Munich
Terje Espevik: Institute of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, 7491, Norway
Egil Lien: Department of Infectious Diseases and Immunology and,
Katherine A. Fitzgerald: Department of Infectious Diseases and Immunology and,
Kenneth L. Rock: University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Kathryn J. Moore: New York University, New York, New York 10016, USA
Samuel D. Wright: Cardiovascular Therapeutics, CSL Limited, Parkville, Victoria 3052, Australia
Veit Hornung: Harvard Medical School, Lipid Metabolism Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Eicke Latz: Department of Infectious Diseases and Immunology and,

Nature, 2010, vol. 464, issue 7293, 1357-1361

Abstract: Cholesterol crystals cleared A study in atherosclerosis-prone (apolipoprotein E-deficient) mice on a high cholesterol diet shows that small cholesterol crystals appear in the earliest stages of atherogenesis, and that these crystals can activate the NLRP3 inflammasome in phagocytes. This suggests that therapeutic strategies that reduce cholesterol crystal deposition or block the inflammasome pathway may have anti-atherosclerotic activity.

Date: 2010
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DOI: 10.1038/nature08938

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