Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis

Sergio E. Baranzini (), Joann Mudge, Jennifer C. van Velkinburgh, Pouya Khankhanian, Irina Khrebtukova, Neil A. Miller, Lu Zhang, Andrew D. Farmer, Callum J. Bell, Ryan W. Kim, Gregory D. May, Jimmy E. Woodward, Stacy J. Caillier, Joseph P. McElroy, Refujia Gomez, Marcelo J. Pando, Leonda E. Clendenen, Elena E. Ganusova, Faye D. Schilkey, Thiruvarangan Ramaraj, Omar A. Khan, Jim J. Huntley, Shujun Luo, Pui-yan Kwok, Thomas D. Wu, Gary P. Schroth, Jorge R. Oksenberg, Stephen L. Hauser and Stephen F. Kingsmore ()
Additional contact information
Sergio E. Baranzini: University of California at San Francisco, San Francisco, California 94143, USA
Joann Mudge: National Center for Genome Resources, Santa Fe, New Mexico 87505, USA
Jennifer C. van Velkinburgh: National Center for Genome Resources, Santa Fe, New Mexico 87505, USA
Pouya Khankhanian: University of California at San Francisco, San Francisco, California 94143, USA
Irina Khrebtukova: Illumina Inc., Hayward, California 94545, USA
Neil A. Miller: National Center for Genome Resources, Santa Fe, New Mexico 87505, USA
Lu Zhang: Illumina Inc., Hayward, California 94545, USA
Andrew D. Farmer: National Center for Genome Resources, Santa Fe, New Mexico 87505, USA
Callum J. Bell: National Center for Genome Resources, Santa Fe, New Mexico 87505, USA
Ryan W. Kim: National Center for Genome Resources, Santa Fe, New Mexico 87505, USA
Gregory D. May: National Center for Genome Resources, Santa Fe, New Mexico 87505, USA
Jimmy E. Woodward: National Center for Genome Resources, Santa Fe, New Mexico 87505, USA
Stacy J. Caillier: University of California at San Francisco, San Francisco, California 94143, USA
Joseph P. McElroy: University of California at San Francisco, San Francisco, California 94143, USA
Refujia Gomez: University of California at San Francisco, San Francisco, California 94143, USA
Marcelo J. Pando: Stanford Medical School Blood Center, Palo Alto, California 94303, USA
Leonda E. Clendenen: National Center for Genome Resources, Santa Fe, New Mexico 87505, USA
Elena E. Ganusova: National Center for Genome Resources, Santa Fe, New Mexico 87505, USA
Faye D. Schilkey: National Center for Genome Resources, Santa Fe, New Mexico 87505, USA
Thiruvarangan Ramaraj: National Center for Genome Resources, Santa Fe, New Mexico 87505, USA
Omar A. Khan: Wayne State Medical School, Detroit, Michigan 48201, USA
Jim J. Huntley: Illumina Inc., Hayward, California 94545, USA
Shujun Luo: Illumina Inc., Hayward, California 94545, USA
Pui-yan Kwok: Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California 94143, USA
Thomas D. Wu: Genentech Inc., South San Francisco, California 94080, USA
Gary P. Schroth: Illumina Inc., Hayward, California 94545, USA
Jorge R. Oksenberg: University of California at San Francisco, San Francisco, California 94143, USA
Stephen L. Hauser: University of California at San Francisco, San Francisco, California 94143, USA
Stephen F. Kingsmore: National Center for Genome Resources, Santa Fe, New Mexico 87505, USA

Nature, 2010, vol. 464, issue 7293, 1351-1356

Abstract: The genomics of multiple sclerosis Identical (or more correctly 'monozygotic') twins are widely used to study the contributions of genetics and environment to human disease. A study that focused on three pairs of monozygotic twins, in which one twin had multiple sclerosis and the other did not, has brought the latest techniques of genome sequencing and analysis to this field, and incidentally published the first female human genome sequences. Full sequences were determined for one pair of twins, and for these and the other two pairs the mRNA transcriptome and epigenome sequences of CD4+ lymphocytes were determined. The striking result is that no genetic, epigenetic or transcriptome differences were found that explained why one twin had the disease and the other did not. Digging deeper into the data, eQTL (expression quantitative trait locus) mapping revealed tantalizing differences within twin pairs that merit closer examination. And some possible causes can be ruled out. Future work might usefully concentrate on studies of other cell types and epigenetic modifications.

Date: 2010
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature08990 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:464:y:2010:i:7293:d:10.1038_nature08990

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature08990

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().