An RNA polymerase II- and AGO4-associated protein acts in RNA-directed DNA methylation

Zhihuan Gao, Hai-Liang Liu, Lucia Daxinger, Olga Pontes, Xinjian He, Weiqiang Qian, Huixin Lin, Mingtang Xie, Zdravko J. Lorkovic, Shoudong Zhang, Daisuke Miki, Xiangqiang Zhan, Dominique Pontier, Thierry Lagrange, Hailing Jin, Antonius J. M. Matzke, Marjori Matzke, Craig S. Pikaard and Jian-Kang Zhu ()
Additional contact information
Zhihuan Gao: University of California, Riverside, California 92521, USA
Hai-Liang Liu: University of California, Riverside, California 92521, USA
Lucia Daxinger: Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences
Olga Pontes: Washington University, St Louis, Missouri 63130, USA
Xinjian He: University of California, Riverside, California 92521, USA
Weiqiang Qian: University of California, Riverside, California 92521, USA
Huixin Lin: University of California, Riverside, California 92521, USA
Mingtang Xie: University of California, Riverside, California 92521, USA
Zdravko J. Lorkovic: Max F. Perutz Laboratory, Medical University of Vienna
Shoudong Zhang: University of California, Riverside, California 92521, USA
Daisuke Miki: University of California, Riverside, California 92521, USA
Xiangqiang Zhan: University of California, Riverside, California 92521, USA
Dominique Pontier: LGDP, CNRS/IRD/Université de Perpignan, UMR 5096, 66860 Perpignan, France
Thierry Lagrange: LGDP, CNRS/IRD/Université de Perpignan, UMR 5096, 66860 Perpignan, France
Hailing Jin: University of California, Riverside, California 92521, USA
Antonius J. M. Matzke: Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences
Marjori Matzke: Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences
Craig S. Pikaard: Indiana University, Bloomington, Indiana 47405, USA
Jian-Kang Zhu: University of California, Riverside, California 92521, USA

Nature, 2010, vol. 465, issue 7294, 106-109

Abstract: RNA-directed DNA methylation in Arabidopsis Small interfering RNAs (siRNAs) are important regulators of gene expression in the plant model Arabidopsis, and intriguingly the vast majority of the small RNAs involved are generated from methylated regions of the genome. A previously unknown protein termed RdDM (for regulator of RNA-directed DNA methylation) has now been identified in Arabidopsis, throwing more light on the interactions of epigenetics, DNA methylation and small RNAs in plants. RDM1 is a novel methyl DNA-binding protein that binds to single-stranded methylated DNA: the many methyl DNA-binding proteins known previously in plants and animals bind only to double-stranded methylated DNA. RDM1 interacts with complexes of the effector protein Argonaute 4 (AGO4) with siRNAs to direct de novo DNA methylation and gene silencing.

Date: 2010
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DOI: 10.1038/nature09025

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