Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

Johanna C. Scheuermann, Andrés Gaytán de Ayala Alonso, Katarzyna Oktaba, Nga Ly-Hartig, Robert K. McGinty, Sven Fraterman, Matthias Wilm, Tom W. Muir and Jürg Müller ()
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Johanna C. Scheuermann: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Andrés Gaytán de Ayala Alonso: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Katarzyna Oktaba: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Nga Ly-Hartig: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Robert K. McGinty: The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Sven Fraterman: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Matthias Wilm: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Tom W. Muir: The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Jürg Müller: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany

Nature, 2010, vol. 465, issue 7295, 243-247

Abstract: Histone-modification by the Polycomb system Polycomb group (PcG) proteins are transcriptional repressors that modify chromatin and regulate important developmental genes. One chromatin-modifying activity associated with Polycomb is an enzyme that ubiquitinates histone H2A. Here, Scheuermann et al. find a Drosophila PcG complex with H2A deubiquitination activity that is important for gene repression in vivo. Polycomb gene silencing may thus involve a dynamic balance between H2A ubiquitination and deubiquitination.

Date: 2010
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DOI: 10.1038/nature08966

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