Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay

Fernando Pastor, Despina Kolonias, Paloma H. Giangrande and Eli Gilboa ()
Additional contact information
Fernando Pastor: Dodson Interdisciplinary Immunotherapy Institute, University of Miami Miller School of Medicine Miami
Despina Kolonias: Dodson Interdisciplinary Immunotherapy Institute, University of Miami Miller School of Medicine Miami
Paloma H. Giangrande: Molecular and Cellular Biology Program, University of Iowa, Iowa City, Iowa 52242, USA
Eli Gilboa: Dodson Interdisciplinary Immunotherapy Institute, University of Miami Miller School of Medicine Miami

Nature, 2010, vol. 465, issue 7295, 227-230

Abstract: Stronger tumour antigens Tumour antigens — unlike those of pathogens — tend to illicit weak immune responses, on a par with 'self' antigens. One possible route to effective cancer vaccines, therefore, is via the identification of more potent and broadly expressed tumour antigens. Pastor et al. present an alternative approach, in which new and hence potent antigens are expressed in tumour cells in situ, making disseminated tumour lesions — in immunological terms — more like pathogens. The strategy uses targeted small interfering RNA (siRNA) to suppress nonsense-mediated mRNA decay, which stimulates the production of new antigens and their subsequent rejection by the immune system. Tumour-targeted delivery is mediated by oligonucleotide aptamers linked to the siRNA. Clinical feasibility of the technique was demonstrated in a mouse model, where it was more effective than a commonly used vaccination protocol.

Date: 2010
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature08999 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:465:y:2010:i:7295:d:10.1038_nature08999

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature08999

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().