A proximity-based programmable DNA nanoscale assembly line

Hongzhou Gu, Jie Chao, Shou-Jun Xiao and Nadrian C. Seeman ()
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Hongzhou Gu: New York University, New York, New York 10003, USA
Jie Chao: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Nanjing University
Shou-Jun Xiao: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Nanjing University
Nadrian C. Seeman: New York University, New York, New York 10003, USA

Nature, 2010, vol. 465, issue 7295, 202-205

Abstract: Assembly in the nanoworld Many new functional materials and devices could be made if it were possible to rationally combine different nanometre-scale particles into larger structures. An assembly line operating on the nanometre-scale would be an ideal means for constructing a wide range of complex target structures, and has now been demonstrated in proof-of-principle experiments. It combines three known DNA-based modules — a DNA origami tile as framework and track for the assembly process, a cassette providing cargo delivery from three programmable DNA machines, and a three-'handed', four-'footed' DNA walker that generates the target product by moving along the track and collecting cargo as directed by the program. The assembly line can be programmed to join three different types of gold nanoparticle to form eight possible target products.

Date: 2010
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DOI: 10.1038/nature09026

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