A three-dimensional model of the yeast genome

Zhijun Duan, Mirela Andronescu, Kevin Schutz, Sean McIlwain, Yoo Jung Kim, Choli Lee, Jay Shendure, Stanley Fields, C. Anthony Blau () and William S. Noble ()
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Zhijun Duan: Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98195-8056, USA
Mirela Andronescu: University of Washington, Seattle, Washington 98195-5065, USA
Kevin Schutz: Graduate Program in Molecular and Cellular Biology, University of Washington, Seattle, Washington 98195-5065, USA
Sean McIlwain: University of Washington, Seattle, Washington 98195-5065, USA
Yoo Jung Kim: Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98195-8056, USA
Choli Lee: University of Washington, Seattle, Washington 98195-5065, USA
Jay Shendure: University of Washington, Seattle, Washington 98195-5065, USA
Stanley Fields: University of Washington Seattle
C. Anthony Blau: Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98195-8056, USA
William S. Noble: University of Washington, Seattle, Washington 98195-5065, USA

Nature, 2010, vol. 465, issue 7296, 363-367

Abstract: A genome in 3D The three-dimensional configuration of chromosomes in the nucleus of budding yeast has been determined from a kilobase-resolution map of intra- and inter-chromosomal interactions identified by high-throughput chromosome conformation capture. The genome resembles a water lily in overall shape, with 32 chromosome arms jutting out from a base of clustered centromeres at one pole of the nucleus. The 3D map, a snapshot that ignores the dynamic nature of chromosomes, provides a first glimpse into the architecture of a eukaryotic genome at high resolution, highlighting the three-dimensional complexity of the genome of even this simple organism. Further work should unveil the general organizing principles by which the DNA sequence specifies this structure.

Date: 2010
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DOI: 10.1038/nature08973

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