Cell signalling by microRNA165/6 directs gene dose-dependent root cell fate

Annelie Carlsbecker, Ji-Young Lee, Christina J. Roberts, Jan Dettmer, Satu Lehesranta, Jing Zhou, Ove Lindgren, Miguel A. Moreno-Risueno, Anne Vatén, Siripong Thitamadee, Ana Campilho, Jose Sebastian, John L. Bowman, Ykä Helariutta () and Philip N. Benfey ()
Additional contact information
Annelie Carlsbecker: University of Helsinki
Ji-Young Lee: Boyce Thompson Institute for Plant Research, Tower Road, Ithaca, New York 14853, USA
Christina J. Roberts: Evolutionary Biology Center, Uppsala University, Norbyvägen 18D, SE-752 36 Uppsala, Sweden
Jan Dettmer: University of Helsinki
Satu Lehesranta: University of Helsinki
Jing Zhou: Boyce Thompson Institute for Plant Research, Tower Road, Ithaca, New York 14853, USA
Ove Lindgren: University of Helsinki
Miguel A. Moreno-Risueno: Duke University, Durham, North Carolina 27708, USA
Anne Vatén: University of Helsinki
Siripong Thitamadee: University of Helsinki
Ana Campilho: University of Helsinki
Jose Sebastian: Boyce Thompson Institute for Plant Research, Tower Road, Ithaca, New York 14853, USA
John L. Bowman: School of Biological Sciences, Monash University, Melbourne, Victoria 3800, Australia
Ykä Helariutta: University of Helsinki
Philip N. Benfey: Duke University, Durham, North Carolina 27708, USA

Nature, 2010, vol. 465, issue 7296, 316-321

Abstract: Abstract A key question in developmental biology is how cells exchange positional information for proper patterning during organ development. In plant roots the radial tissue organization is highly conserved with a central vascular cylinder in which two water conducting cell types, protoxylem and metaxylem, are patterned centripetally. We show that this patterning occurs through crosstalk between the vascular cylinder and the surrounding endodermis mediated by cell-to-cell movement of a transcription factor in one direction and microRNAs in the other. SHORT ROOT, produced in the vascular cylinder, moves into the endodermis to activate SCARECROW. Together these transcription factors activate MIR165a and MIR166b. Endodermally produced microRNA165/6 then acts to degrade its target mRNAs encoding class III homeodomain-leucine zipper transcription factors in the endodermis and stele periphery. The resulting differential distribution of target mRNA in the vascular cylinder determines xylem cell types in a dosage-dependent manner.

Date: 2010
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DOI: 10.1038/nature08977

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