Opposing roles for calcineurin and ATF3 in squamous skin cancer

Xunwei Wu, Bach-Cuc Nguyen, Piotr Dziunycz, Sungeun Chang, Yang Brooks, Karine Lefort, Günther F. L. Hofbauer and G. Paolo Dotto ()
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Xunwei Wu: Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
Bach-Cuc Nguyen: Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
Piotr Dziunycz: University Hospital Zurich
Sungeun Chang: Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
Yang Brooks: Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
Karine Lefort: University of Lausanne
Günther F. L. Hofbauer: University Hospital Zurich
G. Paolo Dotto: Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA

Nature, 2010, vol. 465, issue 7296, 368-372

Abstract: Calcineurin versus ATF3 in cancer Squamous cell carcinoma (SCC) of the skin is a common complication of immunosuppressive treatment with calcineurin inhibitors in graft-recipient patients. Here it is shown that the intact calcineurin/NFAT signalling pathway is important for suppressing SCC development, with a key role for increased expression of the ATF3 transcription factor in tumorigenesis.

Date: 2010
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DOI: 10.1038/nature08996

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