Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection

Andrej Košmrlj, Elizabeth L. Read, Ying Qi, Todd M. Allen, Marcus Altfeld, Steven G. Deeks, Florencia Pereyra, Mary Carrington, Bruce D. Walker () and Arup K. Chakraborty ()
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Andrej Košmrlj: Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts 02114, USA
Elizabeth L. Read: Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts 02114, USA
Ying Qi: Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA
Todd M. Allen: Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts 02114, USA
Marcus Altfeld: Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts 02114, USA
Steven G. Deeks: University of California, San Francisco, California 94110, USA
Florencia Pereyra: Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts 02114, USA
Mary Carrington: Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts 02114, USA
Bruce D. Walker: Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts 02114, USA
Arup K. Chakraborty: Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts 02114, USA

Nature, 2010, vol. 465, issue 7296, 350-354

Abstract: Resisting HIV infection Certain HIV-infected individuals, termed 'elite controllers', maintain extremely low viral loads over long time periods without therapy. A number of HLA class I alleles are enriched in these individuals, most prominently HLA-B57. The paper provides a model of how elite controllers might generate an effective immune response against HIV. According to the model, HLA-B57 binds fewer self-peptides, resulting in a T-cell repertoire with enhanced cross-reactivity and leading to a more effective T-cell response against the virus. This work may have implications for vaccination strategies.

Date: 2010
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DOI: 10.1038/nature08997

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