Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma

Sebastian Lourido, Joel Shuman, Chao Zhang, Kevan M. Shokat, Raymond Hui and L. David Sibley ()
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Sebastian Lourido: Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA
Joel Shuman: Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA
Chao Zhang: Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California 94158, USA
Kevan M. Shokat: Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California 94158, USA
Raymond Hui: Structural Genomics Consortium, University Toronto, MaRS South Tower, Suite 732, 101 College Street, Toronto, Canada M5G 1L7
L. David Sibley: Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA

Nature, 2010, vol. 465, issue 7296, 359-362

Abstract: Kinase target in Toxoplasma gondii The protozoon Toxoplasma gondii, an opportunistic human pathogen, secretes organelles called micronemes, which play a key role in parasite motility, host-cell invasion and egress. This process is now shown to involve the T. gondii calcium dependent protein kinase 1 (TgCDPK1). The lack of this kinase family in mammalian hosts makes this protein an attractive target for drug design.

Date: 2010
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DOI: 10.1038/nature09022

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