Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization

Tadayuki Iwase (), Yoshio Uehara, Hitomi Shinji, Akiko Tajima, Hiromi Seo, Koji Takada, Toshihiko Agata and Yoshimitsu Mizunoe
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Tadayuki Iwase: The Jikei University School of Medicine
Yoshio Uehara: Kochi Medical School
Hitomi Shinji: The Jikei University School of Medicine
Akiko Tajima: The Jikei University School of Medicine
Hiromi Seo: Kochi Medical School
Koji Takada: The Jikei University School of Medicine
Toshihiko Agata: The Jikei University School of Medicine
Yoshimitsu Mizunoe: The Jikei University School of Medicine

Nature, 2010, vol. 465, issue 7296, 346-349

Abstract: Abstract Commensal bacteria are known to inhibit pathogen colonization; however, complex host–microbe and microbe–microbe interactions have made it difficult to gain a detailed understanding of the mechanisms involved in the inhibition of colonization1. Here we show that the serine protease Esp2,3 secreted by a subset of Staphylococcus epidermidis, a commensal bacterium, inhibits biofilm formation and nasal colonization by Staphylococcus aureus, a human pathogen4. Epidemiological studies have demonstrated that the presence of Esp-secreting S. epidermidis in the nasal cavities of human volunteers correlates with the absence of S. aureus. Purified Esp inhibits biofilm formation and destroys pre-existing S. aureus biofilms. Furthermore, Esp enhances the susceptibility of S. aureus in biofilms to immune system components. In vivo studies have shown that Esp-secreting S. epidermidis eliminates S. aureus nasal colonization. These findings indicate that Esp hinders S. aureus colonization in vivo through a novel mechanism of bacterial interference, which could lead to the development of novel therapeutics to prevent S. aureus colonization and infection.

Date: 2010
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DOI: 10.1038/nature09074

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