Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

Suphansa Sawamiphak, Sascha Seidel, Clara L. Essmann, George A. Wilkinson, Mara E. Pitulescu, Till Acker and Amparo Acker-Palmer ()
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Suphansa Sawamiphak: Frankfurt Institute for Molecular Life Sciences and Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt am Main, Germany
Sascha Seidel: Institute of Neuropathology, Giessen University, Arndtstrasse 16, D-35392 Giessen, Germany
Clara L. Essmann: Frankfurt Institute for Molecular Life Sciences and Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt am Main, Germany
George A. Wilkinson: Developmental Vascular Biology Program, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
Mara E. Pitulescu: Max-Planck-Institute for Molecular Biomedicine, and Faculty of Medicine, University of Münster, Röntgenstrasse 20, D-48149 Münster, Germany
Till Acker: Institute of Neuropathology, Giessen University, Arndtstrasse 16, D-35392 Giessen, Germany
Amparo Acker-Palmer: Frankfurt Institute for Molecular Life Sciences and Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt am Main, Germany

Nature, 2010, vol. 465, issue 7297, 487-491

Abstract: Ephrin-B2/VEGF in angiogenesis control Ephrin-B ligands are well known as axon guidance molecules. Ephrin-B2 is also known to play a role in angiogenic remodelling. Two studies now show that signalling through ephrin-B2 controls vessel sprouting. Mechanistically, ephrin-B2 seems to function in part by regulating VEGFR internalization and signalling. The finding suggests that blocking ephrin-B2 signalling may be an alternative approach to blocking VEGFR function in angiogenesis.

Date: 2010
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DOI: 10.1038/nature08995

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