Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization

Carson K. Lam, Taehwan Yoo, Bennett Hiner, Zhiqiang Liu and Jaime Grutzendler ()
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Carson K. Lam: Northwestern University Feinberg School of Medicine, Chicago, Ilinois 60611 USA
Taehwan Yoo: Northwestern University Feinberg School of Medicine, Chicago, Ilinois 60611 USA
Bennett Hiner: Northwestern University Feinberg School of Medicine, Chicago, Ilinois 60611 USA
Zhiqiang Liu: Northwestern University Feinberg School of Medicine, Chicago, Ilinois 60611 USA
Jaime Grutzendler: Northwestern University Feinberg School of Medicine, Chicago, Ilinois 60611 USA

Nature, 2010, vol. 465, issue 7297, 478-482

Abstract: Cerebral blood flow: grab and flow Throughout our lives, tiny blood clots or microemboli develop in the blood vessels of the brain. Many are removed by the force of the blood flow and others are digested by fibrinolysis. Now a third embolus removal mechanism has been discovered: embolus extravasation. High-resolution fixed tissue microscopy and two-photon imaging in live mice shows that many microemboli are not lysed by blood or fibrinolysis, but are instead actively removed within a week by endothelial cells that envelop the emboli, as the underlying endothelium is remodelled to produce an unblocked blood vessel. This process takes longer in aged mice, suggesting that clot-clearance is a possible therapeutic target in patients recovering from a stroke or for age-related cognitive disorders.

Date: 2010
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DOI: 10.1038/nature09001

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