Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

Yingdi Wang, Masanori Nakayama, Mara E. Pitulescu, Tim S. Schmidt, Magdalena L. Bochenek, Akira Sakakibara, Susanne Adams, Alice Davy, Urban Deutsch, Urs Lüthi, Alcide Barberis, Laura E. Benjamin, Taija Mäkinen, Catherine D. Nobes and Ralf H. Adams ()
Additional contact information
Yingdi Wang: Vascular Development Laboratory, Cancer Research UK London Research Institute
Masanori Nakayama: Max-Planck-Institute for Molecular Biomedicine, and Faculty of Medicine, University of Münster
Mara E. Pitulescu: Max-Planck-Institute for Molecular Biomedicine, and Faculty of Medicine, University of Münster
Tim S. Schmidt: Vascular Development Laboratory, Cancer Research UK London Research Institute
Magdalena L. Bochenek: Max-Planck-Institute for Molecular Biomedicine, and Faculty of Medicine, University of Münster
Akira Sakakibara: Vascular Development Laboratory, Cancer Research UK London Research Institute
Susanne Adams: Vascular Development Laboratory, Cancer Research UK London Research Institute
Alice Davy: Centre de Biologie du Développement, Université de Toulouse, CNRS, CBD UMR 5547, F-31062 Toulouse cedex 9, France
Urban Deutsch: Theodor Kocher Institute, University of Berne
Urs Lüthi: Oncalis AG
Alcide Barberis: Oncalis AG
Laura E. Benjamin: Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215-5501, USA
Taija Mäkinen: Cancer Research UK London Research Institute, Lymphatic Development Laboratory
Catherine D. Nobes: School of Medical Sciences, University of Bristol
Ralf H. Adams: Vascular Development Laboratory, Cancer Research UK London Research Institute

Nature, 2010, vol. 465, issue 7297, 483-486

Abstract: Ephrin-B2/VEGF in angiogenesis control Ephrin-B ligands are well known as axon guidance molecules. Ephrin-B2 is also known to play a role in angiogenic remodelling. Two studies now show that signalling through ephrin-B2 controls vessel sprouting. Mechanistically, ephrin-B2 seems to function in part by regulating VEGFR internalization and signalling. The finding suggests that blocking ephrin-B2 signalling may be an alternative approach to blocking VEGFR function in angiogenesis.

Date: 2010
References: Add references at CitEc
Citations: View citations in EconPapers (15)

Downloads: (external link)
https://www.nature.com/articles/nature09002 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:465:y:2010:i:7297:d:10.1038_nature09002

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09002

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().