The mutation spectrum revealed by paired genome sequences from a lung cancer patient

William Lee, Zhaoshi Jiang, Jinfeng Liu, Peter M. Haverty, Yinghui Guan, Jeremy Stinson, Peng Yue, Yan Zhang, Krishna P. Pant, Deepali Bhatt, Connie Ha, Stephanie Johnson, Michael I. Kennemer, Sankar Mohan, Igor Nazarenko, Colin Watanabe, Andrew B. Sparks, David S. Shames, Robert Gentleman, Frederic J. de Sauvage, Howard Stern, Ajay Pandita, Dennis G. Ballinger, Radoje Drmanac, Zora Modrusan, Somasekar Seshagiri and Zemin Zhang ()
Additional contact information
William Lee: Genentech Inc., South San Francisco, California 94080, USA
Zhaoshi Jiang: Genentech Inc., South San Francisco, California 94080, USA
Jinfeng Liu: Genentech Inc., South San Francisco, California 94080, USA
Peter M. Haverty: Genentech Inc., South San Francisco, California 94080, USA
Yinghui Guan: Genentech Inc., South San Francisco, California 94080, USA
Jeremy Stinson: Genentech Inc., South San Francisco, California 94080, USA
Peng Yue: Genentech Inc., South San Francisco, California 94080, USA
Yan Zhang: Genentech Inc., South San Francisco, California 94080, USA
Krishna P. Pant: Complete Genomics Inc., Mountain View, California 94043, USA
Deepali Bhatt: Genentech Inc., South San Francisco, California 94080, USA
Connie Ha: Genentech Inc., South San Francisco, California 94080, USA
Stephanie Johnson: Genentech Inc., South San Francisco, California 94080, USA
Michael I. Kennemer: Complete Genomics Inc., Mountain View, California 94043, USA
Sankar Mohan: Genentech Inc., South San Francisco, California 94080, USA
Igor Nazarenko: Complete Genomics Inc., Mountain View, California 94043, USA
Colin Watanabe: Genentech Inc., South San Francisco, California 94080, USA
Andrew B. Sparks: Complete Genomics Inc., Mountain View, California 94043, USA
David S. Shames: Genentech Inc., South San Francisco, California 94080, USA
Robert Gentleman: Genentech Inc., South San Francisco, California 94080, USA
Frederic J. de Sauvage: Genentech Inc., South San Francisco, California 94080, USA
Howard Stern: Genentech Inc., South San Francisco, California 94080, USA
Ajay Pandita: Genentech Inc., South San Francisco, California 94080, USA
Dennis G. Ballinger: Complete Genomics Inc., Mountain View, California 94043, USA
Radoje Drmanac: Complete Genomics Inc., Mountain View, California 94043, USA
Zora Modrusan: Genentech Inc., South San Francisco, California 94080, USA
Somasekar Seshagiri: Genentech Inc., South San Francisco, California 94080, USA
Zemin Zhang: Genentech Inc., South San Francisco, California 94080, USA

Nature, 2010, vol. 465, issue 7297, 473-477

Abstract: Lung cancer mutations Complete genome sequencing has already provided insights into the mutation spectra of a number of cancer types, including lung cancer. The latest sequencing technologies mean that it is possible to provide a genome-wide view of mutation differences, and this has now been done for lung cancer, comparing the complete sequences of a primary lung tumour — an adenocarcinoma in a male who reported smoking an average of 25 cigarettes a day for 15 years — and adjacent normal tissue. The comparison revealed more than 50,000 point mutations of which 530 were validated, 392 of them in coding regions, including previously known variations such as KRAS proto-oncogene mutation and amplification. The data suggest that genetically complex tumours may contain many partially redundant mutations, and that identifying recurrent cancer-causing driver mutations will require the sequencing of many more samples yet.

Date: 2010
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DOI: 10.1038/nature09004

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