The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death

Junko Sasaki (), Satoshi Kofuji, Reietsu Itoh, Toshihiko Momiyama, Kiyohiko Takayama, Haruka Murakami, Shinsuke Chida, Yuko Tsuya, Shunsuke Takasuga, Satoshi Eguchi, Ken Asanuma, Yasuo Horie, Kouichi Miura, Elizabeth Michele Davies, Christina Mitchell, Masakazu Yamazaki, Hirokazu Hirai, Tadaomi Takenawa, Akira Suzuki and Takehiko Sasaki ()
Additional contact information
Junko Sasaki: Akita University Graduate School of Medicine
Satoshi Kofuji: Akita University Graduate School of Medicine
Reietsu Itoh: Akita University Graduate School of Medicine
Toshihiko Momiyama: Jikei University School of Medicine
Kiyohiko Takayama: Global COE Program, Gunma University and Akita University
Haruka Murakami: Akita University Graduate School of Medicine
Shinsuke Chida: Akita University Graduate School of Medicine
Yuko Tsuya: Akita University Graduate School of Medicine
Shunsuke Takasuga: Akita University Graduate School of Medicine
Satoshi Eguchi: Akita University Graduate School of Medicine
Ken Asanuma: Akita University Graduate School of Medicine
Yasuo Horie: Akita University Graduate School of Medicine
Kouichi Miura: Akita University Graduate School of Medicine
Elizabeth Michele Davies: Monash University, Clayton, Victoria 3800, Australia
Christina Mitchell: Monash University, Clayton, Victoria 3800, Australia
Masakazu Yamazaki: Global COE Program, Gunma University and Akita University
Hirokazu Hirai: Global COE Program, Gunma University and Akita University
Tadaomi Takenawa: Kobe University Graduate School of Medicine
Akira Suzuki: Global COE Program, Gunma University and Akita University
Takehiko Sasaki: Akita University Graduate School of Medicine

Nature, 2010, vol. 465, issue 7297, 497-501

Abstract: INPP4A suppression of excitotoxic neuronal death Junko Sasaki and colleagues demonstrate a critical role for inositol polyphosphate phosphatase 4A (INPP4A), a PtdIns(3,4)P2 phosphatase, in maintaining the integrity of the brain. Mice that lack INPP4A have neurodegeneration in the striatum and suffer from severe involuntary movements. They further show that INPP4A, when present, protects neurons from NMDA type glutamate receptor-mediated excitotoxic cell death. The authors present evidence to suggest that INPP4A can keep neurons alive by downregulating NMDARs and thus decreasing cellular sensitivity to glutamate stimulation.

Date: 2010
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DOI: 10.1038/nature09023

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