Natural allelic variation underlying a major fitness trade-off in Arabidopsis thaliana

Marco Todesco, Sureshkumar Balasubramanian, Tina T. Hu, M. Brian Traw, Matthew Horton, Petra Epple, Christine Kuhns, Sridevi Sureshkumar, Christopher Schwartz, Christa Lanz, Roosa A. E. Laitinen, Yu Huang, Joanne Chory, Volker Lipka, Justin O. Borevitz, Jeffery L. Dangl, Joy Bergelson, Magnus Nordborg and Detlef Weigel ()
Additional contact information
Marco Todesco: Max Planck Institute for Developmental Biology
Sureshkumar Balasubramanian: Max Planck Institute for Developmental Biology
Tina T. Hu: Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089, USA
M. Brian Traw: University of Pittsburgh, Pittsburgh, Pennsylvania 15238, USA
Matthew Horton: University of Chicago, Chicago, Illinois 60637, USA
Petra Epple: University of North Carolina, Chapel Hill, North Carolina 27599, USA
Christine Kuhns: The Sainsbury Laboratory, John Innes Centre, Colney, Norwich NR4 7UH, UK
Sridevi Sureshkumar: Max Planck Institute for Developmental Biology
Christopher Schwartz: Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Christa Lanz: Max Planck Institute for Developmental Biology
Roosa A. E. Laitinen: Max Planck Institute for Developmental Biology
Yu Huang: Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089, USA
Joanne Chory: Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Volker Lipka: The Sainsbury Laboratory, John Innes Centre, Colney, Norwich NR4 7UH, UK
Justin O. Borevitz: University of Chicago, Chicago, Illinois 60637, USA
Jeffery L. Dangl: University of North Carolina, Chapel Hill, North Carolina 27599, USA
Joy Bergelson: University of Chicago, Chicago, Illinois 60637, USA
Magnus Nordborg: Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089, USA
Detlef Weigel: Max Planck Institute for Developmental Biology

Nature, 2010, vol. 465, issue 7298, 632-636

Abstract: The genetics of plant variety Large-scale genome-wide association (GWA) studies have become an important tool in human genomics, mostly focused on disease but also on adaptive variations such as skin colour. The technique is now shown to be similarly useful in plants. Atwell et al. report a GWA study of over a hundred phenotypes in naturally occurring inbred lines of Arabidopsis thaliana. The results range from significant associations, usually for single genes, to more difficult-to-interpret findings that indicate confounding by complex genetics and population structure. The accompanying paper by Todesco et al. demonstrates the ability of this technique to detect major-effect gene loci. Using forward genetics and GWA analyses, they show that variation at a single locus (ACD6) in Arabidopsis underlies phenotypic variation in vegetative growth as well as resistance to infection. The strong enhancement of resistance mediated by one of the alleles at this locus explains its persistence in natural populations throughout the world, despite it drastically reducing new leaf production.

Date: 2010
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DOI: 10.1038/nature09083

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