Control of mammary stem cell function by steroid hormone signalling

Marie-Liesse Asselin-Labat, François Vaillant, Julie M. Sheridan, Bhupinder Pal, Di Wu, Evan R. Simpson, Hisataka Yasuda, Gordon K. Smyth, T. John Martin, Geoffrey J. Lindeman () and Jane E. Visvader ()
Additional contact information
Marie-Liesse Asselin-Labat: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
François Vaillant: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Julie M. Sheridan: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Bhupinder Pal: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Di Wu: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Evan R. Simpson: Prince Henry’s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria 3168, Australia
Hisataka Yasuda: Nagahama Institute for Biochemical Science, Oriental Yeast Company, Nagahama, Shiga 526-0804, Japan
Gordon K. Smyth: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
T. John Martin: St Vincent’s Institute, Fitzroy, Victoria 3065, Australia
Geoffrey J. Lindeman: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Jane E. Visvader: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia

Nature, 2010, vol. 465, issue 7299, 798-802

Abstract: Mammary stem cell control The ovarian hormones oestrogen and progesterone are involved in a complicated series of interactions in the mammary glands from the beginning of puberty to the menopause. Many of these changes are associated with cell proliferation, and breast cancer can result when errors occur. Two studies in this issue examine the effects of oestrogen and progesterone on mouse mammary stem cell (MaSC) function. They find that MaSC numbers decrease in virgin mice in the absence of both hormones due to ovariectomy or drug blockade, but increase with oestrogen and progesterone treatment. In addition, both groups implicate RANKL, a progesterone target known to be involved in bone remodelling and mammary gland formation, as an intermediary in the MaSC response to progesterone.

Date: 2010
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DOI: 10.1038/nature09027

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