Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2

Filipp Frank, Nahum Sonenberg and Bhushan Nagar ()
Additional contact information
Filipp Frank: McGill University, Montréal, Québec H3G 0B1, Canada
Nahum Sonenberg: McGill University, Montréal, Québec H3G 0B1, Canada
Bhushan Nagar: McGill University, Montréal, Québec H3G 0B1, Canada

Nature, 2010, vol. 465, issue 7299, 818-822

Abstract: Messenger RNAs: an end in the MIDdle The association of small RNAs, such as microRNAs (miRNAs), with Argonaute (AGO) family proteins yields complexes that regulate gene expression. While bacterial and archaeal miRNAs show no sequence preference at their 5′ ends, eukaryotic miRNAs tend to have 5′ U or A. To determine the basis of this preference, Bhushan Nagar and colleagues have solved the structure of the human AGO2 MID domain complexed with ribonucleotide monophosphates. The structure reveals a specific interaction of UMP and AMP with a loop that also discriminates against CMP or GMP.

Date: 2010
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature09039 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:465:y:2010:i:7299:d:10.1038_nature09039

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09039

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().