Distinct FGFs promote differentiation of excitatory and inhibitory synapses

Akiko Terauchi, Erin M. Johnson-Venkatesh, Anna B. Toth, Danish Javed, Michael A. Sutton and Hisashi Umemori ()
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Akiko Terauchi: Molecular and Behavioral Neuroscience Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109-2200, USA
Erin M. Johnson-Venkatesh: Molecular and Behavioral Neuroscience Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109-2200, USA
Anna B. Toth: Molecular and Behavioral Neuroscience Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109-2200, USA
Danish Javed: Molecular and Behavioral Neuroscience Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109-2200, USA
Michael A. Sutton: Molecular and Behavioral Neuroscience Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109-2200, USA
Hisashi Umemori: Molecular and Behavioral Neuroscience Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109-2200, USA

Nature, 2010, vol. 465, issue 7299, 783-787

Abstract: Excitatory and inhibitory synapses: FGF signalling tips the balance For the brain to function properly, the excitatory synapses — which push target neurons to fire more — need to be balanced by inhibitory ones. But how this is wired up during development has been unclear. Now Hisashi Umemori and colleagues show that two members of the fibroblast growth factor family, the cell–cell signalling molecules FGF22 and FGF7, promote the formation of excitatory and inhibitory synapses, respectively. Genetic ablation of FGF22 produces mice that are resistant to the induction of epilepsy, while FGF7-deficient mice are prone to seizures. Future work should address whether these FGFs are expressed abnormally in epileptic patients, and whether the application or blockade of FGFs/FGFRs alleviates seizures.

Date: 2010
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DOI: 10.1038/nature09041

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