Progesterone induces adult mammary stem cell expansion

Purna A. Joshi, Hartland W. Jackson, Alexander G. Beristain, Marco A. Di Grappa, Patricia A. Mote, Christine L. Clarke, John Stingl, Paul D. Waterhouse and Rama Khokha ()
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Purna A. Joshi: Ontario Cancer Institute, University of Toronto, Toronto M5G 2M9, Ontario, Canada
Hartland W. Jackson: Ontario Cancer Institute, University of Toronto, Toronto M5G 2M9, Ontario, Canada
Alexander G. Beristain: Ontario Cancer Institute, University of Toronto, Toronto M5G 2M9, Ontario, Canada
Marco A. Di Grappa: Ontario Cancer Institute, University of Toronto, Toronto M5G 2M9, Ontario, Canada
Patricia A. Mote: Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead, New South Wales 2145, Australia
Christine L. Clarke: Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead, New South Wales 2145, Australia
John Stingl: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
Paul D. Waterhouse: Ontario Cancer Institute, University of Toronto, Toronto M5G 2M9, Ontario, Canada
Rama Khokha: Ontario Cancer Institute, University of Toronto, Toronto M5G 2M9, Ontario, Canada

Nature, 2010, vol. 465, issue 7299, 803-807

Abstract: Mammary stem cell control The ovarian hormones oestrogen and progesterone are involved in a complicated series of interactions in the mammary glands from the beginning of puberty to the menopause. Many of these changes are associated with cell proliferation, and breast cancer can result when errors occur. Two studies in this issue examine the effects of oestrogen and progesterone on mouse mammary stem cell (MaSC) function. They find that MaSC numbers decrease in virgin mice in the absence of both hormones due to ovariectomy or drug blockade, but increase with oestrogen and progesterone treatment. In addition, both groups implicate RANKL, a progesterone target known to be involved in bone remodelling and mammary gland formation, as an intermediary in the MaSC response to progesterone.

Date: 2010
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DOI: 10.1038/nature09091

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