Global and local fMRI signals driven by neurons defined optogenetically by type and wiring

Jin Hyung Lee (), Remy Durand, Viviana Gradinaru, Feng Zhang, Inbal Goshen, Dae-Shik Kim, Lief E. Fenno, Charu Ramakrishnan and Karl Deisseroth ()
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Jin Hyung Lee: Psychiatry and Biobehavioral Sciences, Bioengineering, and Radiology, University of California, Los Angeles, California 90095, USA
Remy Durand: Stanford University, Stanford, California 94305, USA
Viviana Gradinaru: Stanford University, Stanford, California 94305, USA
Feng Zhang: Stanford University, Stanford, California 94305, USA
Inbal Goshen: Stanford University, Stanford, California 94305, USA
Dae-Shik Kim: Korea Advanced Institute of Science and Technology (KAIST)
Lief E. Fenno: Stanford University, Stanford, California 94305, USA
Charu Ramakrishnan: Stanford University, Stanford, California 94305, USA
Karl Deisseroth: Stanford University, Stanford, California 94305, USA

Nature, 2010, vol. 465, issue 7299, 788-792

Abstract: Why fMRI scanning works Functional magnetic resonance imaging (fMRI) studies are widely used to determine which brain regions are active during particular tasks or behaviours. There is much controversy over the source and interpretation of the BOLD (blood oxygenation level-dependent) signals that this imaging technique detects. Now, using fMRI in combination with optogenetics, a group of excitatory neurons in the rat brain has been identified as a source of the BOLD signals.

Date: 2010
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DOI: 10.1038/nature09108

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