Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

Megan T. Baldridge, Katherine Y. King, Nathan C. Boles, David C. Weksberg and Margaret A. Goodell ()
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Megan T. Baldridge: Baylor College of Medicine, Houston, Texas 77030, USA
Katherine Y. King: Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas 77030, USA
Nathan C. Boles: Baylor College of Medicine, Houston, Texas 77030, USA
David C. Weksberg: Baylor College of Medicine, Houston, Texas 77030, USA
Margaret A. Goodell: Baylor College of Medicine, Houston, Texas 77030, USA

Nature, 2010, vol. 465, issue 7299, 793-797

Abstract: Response to chronic bacterial infection Using a mouse model of bacterial infection, Baldridge et al. show that infection with Mycobacterium avium exerts a powerful stimulatory effect on haematopoietic stem cells, and that this stimulation is mediated by interferon-γ. Circulating immune cells in the blood are consumed during infection, and this work suggests that primitive stem cells in the marrow have a role in their replacement. These findings have implications for the use of interferon-γ as a therapeutic agent during chronic infections such as HIV/AIDS or tuberculosis and for recovery from bone marrow transplantation.

Date: 2010
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DOI: 10.1038/nature09135

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